[HTML][HTML] Voriconazole: a review of population pharmacokinetic analyses

C Shi, Y Xiao, Y Mao, J Wu, N Lin - Clinical pharmacokinetics, 2019 - Springer
Numerous population pharmacokinetic studies on voriconazole have been conducted in
recent years. This review aimed to comprehensively summarize the population …

Safety and pharmacokinetics of oral voriconazole in patients at risk of fungal infection: a dose escalation study

HM Lazarus, JL Blumer, S Yanovich… - The Journal of …, 2002 - Wiley Online Library
The objective of this study was to investigate the safety, tolembility, and pharmacokinetics of
oral voriconazole in subjects at high risk of developing fungal infections. This was a …

Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole

R Hyland, BC Jones, DA Smith - Drug Metabolism and Disposition, 2003 - ASPET
Voriconazole is a triazole antifungal agent with potent activity against a broad spectrum of
clinically significant pathogens. In vivo and in vitro studies have demonstrated that …

Practice guidelines for therapeutic drug monitoring of voriconazole: a consensus review of the Japanese Society of Chemotherapy and the Japanese Society of …

Y Hamada, I Tokimatsu, H Mikamo, M Kimura… - Journal of Infection and …, 2013 - Elsevier
Voriconazole (VRCZ) is a triazole antifungal developed for the treatment of fungal infectious
disease and is available for both oral and intravenous administration. It has potent activity …

Effect of food on the pharmacokinetics of multiple‐dose oral voriconazole

L Purkins, N Wood, D Kleinermans… - British journal of …, 2003 - Wiley Online Library
Aims Voriconazole is a new triazole antifungal agent with activity against a range of clinically
important and emerging pathogens. This study determined the effect of food on the …

Comprehensive in vitro analysis of voriconazole inhibition of eight cytochrome P450 (CYP) enzymes: major effect on CYPs 2B6, 2C9, 2C19, and 3A

S Jeong, PD Nguyen, Z Desta - Antimicrobial agents and …, 2009 - Am Soc Microbiol
Voriconazole is an effective antifungal drug, but adverse drug-drug interactions associated
with its use are of major clinical concern. To identify the mechanisms of these interactions …

Voriconazole, a novel wide‐spectrum triazole: oral pharmacokinetics and safety

L Purkins, N Wood, K Greenhalgh… - British Journal of …, 2003 - Wiley Online Library
Aims Voriconazole is a potent new triazole with broad‐spectrum antifungal activity against
clinically significant and emerging pathogens. The present study evaluated the safety …

The pharmacokinetics and safety of intravenous voriconazole–a novel wide‐spectrum antifungal agent

L Purkins, N Wood, K Greenhalgh… - British journal of …, 2003 - Wiley Online Library
Aims Voriconazole is a new triazole with broad‐spectrum antifungal activity against clinically
significant and emerging pathogens. These studies evaluated the pharmacokinetics and …

PharmGKB summary: voriconazole pathway, pharmacokinetics

JM Barbarino, AO Obeng, TE Klein… - Pharmacogenetics and …, 2017 - journals.lww.com
Pharmacokinetics A schematic representation of voriconazole disposition within the body is
provided in Fig. 1. Voriconazole is extensively metabolized, with less than 2% of the original …

Voriconazole in clinical practice

M Mikulska, A Novelli, F Aversa, S Cesaro… - Journal of …, 2012 - Taylor & Francis
Invasive fungal diseases are associated with significant morbidity and mortality in
immunocompromized patients. Voriconazole is the first line treatment of invasive …