Review on metal-based nanoparticles: role of reactive oxygen species in renal toxicity

P Makhdoumi, H Karimi, M Khazaei - Chemical Research in …, 2020 - ACS Publications
The rapidly emerging field of nanotechnology has offered innovative discoveries. Due to a
wide variety of nanotechnology applications in the industrial, medical, and consumptive …

Nanomedicines for renal disease: current status and future applications

N Kamaly, JC He, DA Ausiello… - Nature Reviews …, 2016 - nature.com
Abstract Treatment and management of kidney disease currently presents an enormous
global burden, and the application of nanotechnology principles to renal disease therapy …

ROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule

D Liu, G Shu, F Jin, J Qi, X Xu, Y Du, H Yu, J Wang… - Science …, 2020 - science.org
The development of drugs with rapid distribution in the kidney and long-term retention in the
renal tubule is a breakthrough for enhanced treatment of acute kidney injury (AKI). Here, l …

Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI

D Zou, R Ganugula, M Arora… - American Journal …, 2019 - journals.physiology.org
The popular anticancer drug cisplatin causes many adverse side effects, the most serious of
which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies …

Oral administration of Si-based agent attenuates oxidative stress and ischemia-reperfusion injury in a rat model: a novel hydrogen administration method

M Kawamura, R Imamura, Y Kobayashi… - Frontiers in …, 2020 - frontiersin.org
Organ ischemia-reperfusion injury (IRI), which is unavoidable in kidney transplantation,
induces the formation of reactive oxygen species and causes organ damage. Although the …

Physiological principles underlying the kidney targeting of renal nanomedicines

Y Huang, X Ning, S Ahrari, Q Cai, N Rajora… - Nature Reviews …, 2024 - nature.com
Kidney disease affects more than 10% of the global population and is associated with
considerable morbidity and mortality, highlighting a need for new therapeutic options …

Restoring cellular calcium homeostasis to rescue ER stress by 1, 2-bis (2-aminophenoxy) ethane-N, N, N′, N′-tetraacetic acid acetoxymethyl ester-loaded lipid …

J Zhang, J Yan, Y Wang, H Liu, X Sun, Y Gu, L Yu… - Chinese Chemical …, 2024 - Elsevier
Early pathogenesis of ischemia-reperfusion (I/R)-induced acute kidney injury (AKI) is
dominated by intracellular calcium overload, which induces oxidative stress, intracellular …

An Ultrasmall RuO2 Nanozyme Exhibiting Multienzyme-like Activity for the Prevention of Acute Kidney Injury

Z Liu, L Xie, K Qiu, X Liao, TW Rees… - … applied materials & …, 2020 - ACS Publications
Oxidative stress induced by reactive oxygen species (ROS) is one of the major pathological
mechanisms of acute kidney injury (AKI). Inorganic nanomaterial-mediated antioxidant …

[HTML][HTML] Unveiling drug induced nephrotoxicity using novel biomarkers and cutting-edge preventive strategies

A Džidić-Krivić, EK Sher, J Kusturica, EK Farhat… - Chemico-Biological …, 2023 - Elsevier
Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various
diseases and it accounts for around 25% of serious side-effects reported after drug …

Nanotechnology, nanomedicine, and the kidney

PV Hauser, HM Chang, N Yanagawa, M Hamon - Applied Sciences, 2021 - mdpi.com
The kidneys are vital organs performing several essential functions. Their primary function is
the filtration of blood and the removal of metabolic waste products as well as fluid …