Although the prevailing concept has been that mortality in sepsis results from an unbridled
hyper-inflammatory cytokine-mediated response, the failure of more than 30 clinical trials to …

The treatment of sepsis and septic shock remains a clinical conundrum, and recent
prospective trials with biological response modifiers aimed at the inflammatory response …

Sepsis, a widely prevalent disease with increasing morbidity and mortality, is thought to
result from uncontrolled inflammatory responses to microbial infection and/or components …

The inability of present therapies to mitigate the devastating effects of sepsis and multiple
organ failure in the critically ill patient indicates that more knowledge of the pathophysiology …

Sepsis induces extensive lymphocyte apoptosis, a process which may be beneficial to host
survival by down-regulating the inflammatory response or, alternatively, harmful by impairing …

Recent research has yielded many interesting and potentially important therapeutic targets
in sepsis. Specifically, the effects of antagonistic anti-cytokine therapies (tumor necrosis …

Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies
available other than ICU treatment. The patient outcome is determined by a complex …

Sepsis is a life-threatening illness that occurs due to an abnormal host immune network
which extends through the initial widespread and overwhelming inflammation, and …

Sepsis with subsequent multiple-organ dysfunction is a distinct systemic inflammatory
response to concealed or obvious infection, and it is a leading cause of death in intensive …

Sepsis demonstrates a marked dysregulation of the immune system in its ability to fight
infection. Previous models have focused on the mechanisms which upregulate and sustain …