Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes

T van der Molen, M Cazzola - Primary Care Respiratory Journal, 2012 - nature.com
Bronchodilators are central to the management of chronic obstructive pulmonary disease
(COPD). Clinical studies combining different classes of bronchodilators, in particular a long …

Dual bronchodilation in COPD: lung function and patient-reported outcomes–a review

D Price, A Østrem, M Thomas… - International journal of …, 2016 - Taylor & Francis
Several fixed-dose combinations (FDCs) of long-acting bronchodilators (a long-acting
muscarinic antagonist [LAMA] plus a long-acting β2-agonist [LABA]) are available for the …

[HTML][HTML] Optimal bronchodilation for COPD patients: are all long-acting β2-agonist/long-acting muscarinic antagonists the same?

M Miravitlles, S Baek, V Vithlani… - … and respiratory diseases, 2018 - ncbi.nlm.nih.gov
Bronchodilators provide improvements in lung function and reductions in symptoms and
exacerbations, and are the mainstay of pharmacological management of chronic obstructive …

LABA/LAMA combination in COPD: a meta-analysis on the duration of treatment

L Calzetta, P Rogliani, J Ora, E Puxeddu… - European …, 2017 - Eur Respiratory Soc
When there are no randomised clinical trials directly comparing all relevant treatment
options, an indirect treatment comparison via meta-analysis of the available clinical …

LABA/LAMA as first-line therapy for COPD: a summary of the evidence and guideline recommendations

M Miravitlles, T Kawayama, M Dreher - Journal of Clinical Medicine, 2022 - mdpi.com
Inhaled bronchodilators (alone or in combination) are the cornerstone of treatment for
symptomatic patients with COPD, either as initial/first-line treatment or for second …

Quantitative analysis of efficacy and safety of LABA/LAMA fixed-dose combinations in the treatment of stable COPD

Y Gong, Y Lv, H Liu, Q Zheng… - Therapeutic Advances in …, 2022 - journals.sagepub.com
Objective: This study aimed to quantitatively compare the efficacy and safety of long-acting
β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations …

Randomized controlled trials and real-world observational studies in evaluating cardiovascular safety of inhaled bronchodilator therapy in COPD

P Kardos, S Worsley, D Singh… - … journal of chronic …, 2016 - Taylor & Francis
Long-acting muscarinic antagonist (LAMA) or long-acting β2-agonist (LABA) bronchodilators
and their combination are recommended for the maintenance treatment of chronic …

Chronic obstructive pulmonary disease individualized therapy: tailored approach to symptom management

D Singh, M Miravitlles, C Vogelmeier - Advances in therapy, 2017 - Springer
Chronic obstructive pulmonary disease (COPD) is associated with high morbidity and
mortality. COPD is typified by persistent, progressive airflow limitation and a range of …

The MABA approach: a new option to improve bronchodilator therapy

M Cazzola, JL Lopez-Campos… - European Respiratory …, 2013 - Eur Respiratory Soc
Recently, the results of an interesting systematic review have shown that the use of a
combination of a longacting b2-agonist (LABA) and a long-acting antimuscarinic agent …

Efficacy and cardiovascular safety profile of dual bronchodilation therapy in chronic obstructive pulmonary disease: a bidimensional comparative analysis across fixed …

P Rogliani, MG Matera, BL Ritondo, I De Guido… - Pulmonary …, 2019 - Elsevier
Despite several long-acting β 2-adrenoceptor agonist (LABA)/long-acting muscarinic
antagonist (LAMA) fixed-dose combinations (FDCs) are currently approved for the treatment …