The purposes of this study were to determine the separate and interactive functions of
progesterone and estradiol in regulating the cervical prostaglandin (PG) system in pregnant …

In the present study, we examined the in vivo effects of estradiol (E 2) and progesterone on
cyclooxygenase (COX) 2, prostaglandin F synthase (PTGFS, also known as PGFS), and …

The use of transcervical artificial insemination in sheep is limited because of the anatomy of
the cervix, which restricts the passage of an inseminating pipette into the uterine lumen …

The ovine cervix relaxes at estrus allowing easier entry of spermatozoa into the uterus. The
mechanism responsible for this relaxation is not fully elucidated and we hypothesized that …

During the periovulatory period, the cervix of the ewe relaxes and this mechanism is thought
to be mediated by oxytocin and prostaglandin E 2 (PGE 2) in response to increased …

There is a degree of cervical relaxation in the ewe at estrus that is regulated by changes in
prostaglandin synthesis, prostaglandin receptor expression, and changes in the cervical …

The experiments reported here were designed for both in vivo and in vitro approaches in the
same animals to obtain a better picture of the role of estrogen in the control of parturition …

Although prostaglandin E 2 (PGE 2) has been identified as a central mediator of the cervical
ripening process, the mechanisms responsible for PGE 2 ripening are still poorly …

Recent evidence suggests that ovine placental output of prostaglandin (PG) E2 rises
through late gestation partly because of a direct effect of cortisol on PGH2 synthase 2 (PGHS …

Prostaglandin E2 (PGE2) can cause softening of the bovine cervix at oestrus when receptors
for oxytocin (OT) are maximally present, indicating a relationship between OT and PGE2 …