In sheep, fetal cortisol stimulates the conversion of progesterone to estradiol in late gestation
initiating labor. It is unclear whether an intact fetal hypothalamic-pituitary-adrenal (HPA) axis …

Cervical softening was induced in late pregnant sheep by infusion of PGE-2 into a cervical
artery. The effect of this treatment was assessed by measurement of the extensibility in vitro …

Expression of the gene for prostaglandin synthase (PGS) was examined in whole
endometrial tissue derived from ewes during the oestrous cycle (Days 4–14), on Day 15 of …

Porcine trophoblast attachment to the uterine surface is associated with increased
conceptus and endometrial production of prostaglandins. Conceptus secretion of estrogen …

Administration of exogenous prostaglandins at the time of mating may improve fertility via
their effects on uterine contractility. The present study was undertaken to compare the effects …

The objective of this study was to determine whether prostaglandin E 1 (PGE 1) or
prostaglandin E 2 (PGE 2) prevents premature luteolysis in ewes when progesterone is …

It is proposed that in sheep, during the last third of gestation, a progressive increase in the
production of prostaglandin E2 (PGE2) by the fetal trophoblast activates the fetal …

Parturition in the sheep is preceded by an increase in the synthesis of prostaglandins by
intrauterine tissues. Prostaglandin G/H synthase (PGHS) is the central enzyme involved in …

Prostaglandins (PGs) have been implicated as stimulants to myometrial contractility at
parturition in many species. To determine whether the increased production of PGs at …

The mechanism of human parturition is not fully understood. Parturition is best documented
in sheep, but applying this well documented mechanism to human parturition has proven …