There is an urgent need to develop new efficacious antimalarials to address the emerging
drug-resistant clinical cases. Our previous phenotypic screening identified styrylquinoline …

Though malaria mortality rates are down 48% globally since 2000, reported occurrences of
resistance against current therapeutics threaten to reverse that progress. Recently …

ICI 56,780 (5) displayed causal prophylactic and blood schizonticidal activity (ED50= 0.05
mg/kg) in rodent malaria models but produced rapid acquisition of parasitological resistance …

Utilizing mefloquine as a scaffold, a next generation quinoline methanol (NGQM) library was
constructed to identify early lead compounds that possess biological properties consistent …

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-
carboxamides are described. This series was identified from a phenotypic screen against …

We previously reported that substituted 4-aminoquinolines with a phenyl ether substituent at
the 7-position of the quinoline ring and the capability of intramolecular hydrogen bonding …

A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide
derivatives as a novel antimalarial scaffold. Structure–activity relationship studies led to …

The continued proliferation of malaria throughout temperate and tropical regions of the world
has promoted a push for more efficacious treatments to combat the disease. Unfortunately …

Malaria deaths have been decreasing over the last 10–15 years, with global mortality rates
having fallen by 47% since 2000. While the World Health Organization (WHO) recommends …

The 4-aminoquinoline drugs, such as chloroquine (CQ), amodiaquine or piperaquine, are
still commonly used for malaria treatment, either alone (CQ) or in combination with …