Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer …
New acetamide (IV ae) and 1, 3-thiazolidinone derivatives (VII ae) were designed,
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines …
Design, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors
ZY Fang, YH Zhang, CH Chen, Q Zheng… - Chemistry & …, 2022 - Wiley Online Library
A series of novel quinazolinone hydrazide derivatives were designed and synthesized as
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti …
Design, synthesis and evaluation of anti-proliferative activity of 2-aryl-4-aminoquinazoline derivatives as EGFR inhibitors
Abstract A class of 2-aryl-4-aminoquinazoline derivatives (7a-7j, 8a-8h, 9a-9h and 10a-10k)
were designed, synthesized and evaluated as EGFR inhibitors. The anti-proliferative activity …
were designed, synthesized and evaluated as EGFR inhibitors. The anti-proliferative activity …
Design and synthesis of novel quinazolinone-based derivatives as EGFR inhibitors with antitumor activity
Abstract Nineteen new quinazolin-4 (3 H)-one derivatives 3a–g and 6a–l were designed
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
and synthesised to inhibit EGFR. The antiproliferative activity of the synthesised compounds …
Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
Y Le, Y Gan, Y Fu, J Liu, W Li, X Zou… - Journal of enzyme …, 2020 - Taylor & Francis
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed,
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor …
Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity
RM Aly, RAT Serya, AM El-Motwally, A Esmat… - Bioorganic …, 2017 - Elsevier
EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …
Design and Synthesis of some new 2, 4, 6-trisubstituted quinazoline EGFR inhibitors as targeted anticancer agents
The present study describes the synthesis of 6-bromo-2-(pyridin-3-yl)-4-substituted
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
quinazolines starting from 4-chloro derivative VI via the reaction with either phenolic …
Synthesis and preliminary structure-activity relationship study of 3-methylquinazolinone derivatives as EGFR inhibitors with enhanced antiproliferative activities …
Y Zhang, Q Wang, L Li, Y Le, L Liu, J Yang… - Journal of Enzyme …, 2021 - Taylor & Francis
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
studied the preliminary structure-activity relationship for antiproliferative activities. All target …
Novel 4-anilinoquinazoline derivatives featuring an 1-adamantyl moiety as potent EGFR inhibitors with enhanced activity against NSCLC cell lines
With the aim of overcoming gefitinib resistance, a series of novel quinazoline derivatives
bearing an adamantyl group on the aniline ring were synthesized as potent epidermal …
bearing an adamantyl group on the aniline ring were synthesized as potent epidermal …
Facile and efficient synthesis and biological evaluation of 4-anilinoquinazoline derivatives as EGFR inhibitors
Z Wang, X Wu, L Wang, J Zhang, J Liu, Z Song… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract Series of 4-anilinoquinazoline derivatives were conveniently and efficiently
synthesized and their antitumor activities were evaluated by MTT assay in three human …
synthesized and their antitumor activities were evaluated by MTT assay in three human …
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