The field of xenotransplantation is benefiting greatly from recent advances in genetic
engineering. The efficiency and pace with which new model animals are being created has …

Animal models, particularly pigs, have come to play an important role in translational
biomedical research. There have been many pig models with genetically modifications via …

Pigs serve as an important agricultural resource and animal model in biomedical studies.
Efficient and precise modification of pig genome by using recently developed gene editing …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …

Pigs are important livestock for food and have been used in various biomedical studies,
particularly translational research, as experimental animals because of their anatomical and …

Genetically modified animals, especially rodents, are widely used in biomedical research.
However, non-rodent models are required for efficient translational medicine and preclinical …

The growing shortage of available organs is a major problem in transplantology. Thus, new
and alternative sources of organs need to be found. One promising solution could be …

The first genetically modified large animals were generated in 1985 by microinjection to
increase the growth of agricultural livestock such as pigs (1). Since then, it has been a …

The ability to directly manipulate the pig genome through genetic engineering has been
available to the research community for over three decades. This technology has …

The field of xenotransplantation has fluctuated between great optimism and doubts over the
last 50 years. The initial clinical attempts were extremely ambitious but faced technical and …