The shortage of donor resources has greatly limited the application of clinical
xenotransplantation. As such, genetically engineered pigs are expected to be an ideal organ …

Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

During the last two decades, pigs have been used to develop some of the most important
large animal models for biomedical research. Advances in pig genome research, genetic …

While the technique of homologous recombination, or gene targeting, has led to the
generation of transgenic mice of great value to biomedical research, similar approaches are …

The rat has been extensively used as a small animal model. Many genetically engineered
rat models have emerged in the last two decades, and the advent of gene-specific …

Genetic modification of animals via selective breeding is the basis for modern agriculture.
The current breeding paradigm however has limitations, chief among them is the …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

The domestic pig is an ideal “dual purpose” animal model for agricultural and biomedical
research. With the availability of genome editing tools such as clustered regularly …

Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been
used for the generation of transgenic livestock. This technology works reliably, but is …

Background Tools for genome editing in pigs are improving rapidly so that making precise
cuts in DNA for the purposes of deleting genes is straightforward. Development of means to …