Novel germline RET proto-oncogene mutations associated with medullary thyroid carcinoma (MTC): mutation analysis in Japanese patients with MTC

Y Kitamura, PJ Goodfellow, K Shimizu, M Nagahama… - Oncogene, 1997 - nature.com
Germ-like and somatic mutations in the RET proto-oncogene are associated with inherited
and sporadic medullary thyroid carcinoma (MTC). The majority of patients with multiple …

Somatic Mutations in RET Exons 12 and 15 in Sporadic Medullary Thyroid Carcinomas: Different Spectrum of Mutations in Sporadic Type from Hereditary Type

S Uchino, S Noguchi, H Yamashita… - Japanese Journal of …, 1999 - Wiley Online Library
Germline mutations in the RET proto‐oncogene are responsible for multiple endocrine
neoplasia type 2 (MEN 2A and 2B) and familial medullary thyroid carcinoma (FMTC). Point …

Novel Point Mutations and Allele Loss at the RET Locus in Sporadic Medullary Thyroid Carcinomas

S Uchino, S Noguchi, M Adachi, M Sato… - Japanese journal of …, 1998 - Wiley Online Library
Germline mutations in the RET proto‐oncogene have been shown to be the underlying
cause of multiple endocrine neoplasia type 2 (MEN 2A and 2B) and familial medullary …

Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma

S Shirahama, K Ogura, H Takami, K Ito… - Journal of human …, 1998 - nature.com
Multiple endocrine neoplasia types 2A and 2B (MEN2A and MEN2B) and familial medullary
thyroid carcinomas (FMTC) are caused by germline mutations in the RET proto-oncogene …

27-bp deletion in the ret proto-oncogene as a somatic mutation associated with medullary thyroid carcinoma

V Kalinin, A Frilling - Journal of molecular medicine, 1998 - Springer
Medullary thyroid carcinoma (MTC) occurs as a sporadic tumor or in connection with the
inherited cancer syndromes of multiple endocrine neoplasia (MEN) types 2A and 2B and …

Analysis of RET proto-oncogene abnormalities in patients with MEN 2A, MEN 2B, familial or sporadic medullary thyroid carcinoma

E Chiefari, D Russo, D Giuffrida, GA Zampa… - Journal of …, 1998 - Springer
Medullary thyroid carcinoma (MTC) may occur either as a sporadic or familial (FMTC)
disease. Multiple endocrine neoplasia (MEN) type 2, inherited as an autosomal dominant …

RET oncogene mutations in 75 cases of familial medullary thyroid carcinoma in Japan

K Kameyama, H Okinaga, H Takami - Biomedicine & pharmacotherapy, 2004 - Elsevier
The familial form of medullary thyroid carcinoma (MTC) is caused by mutations of the RET
protooncogene. We registered 60 multiple endocrine neoplasia (MEN) 2A patients, 12 …

Mutation of the RET protooncogene in sporadic medullary thyroid carcinoma

C Eng, LM Mulligan, DP Smith… - Genes …, 1995 - Wiley Online Library
Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer
syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense …

New Multiple Somatic Mutations in the RET Proto-oncogene Associated with a Sporadic Medullary Thyroid Carcinoma

Š Dvořáková, E Vaclavikova, V Sýkorová, J Dušková… - Thyroid, 2006 - liebertpub.com
Medullary thyroid carcinoma (MTC) occurs mostly as a sporadic tumor or in connection with
inherited cancer syndromes—multiple endocrine neoplasia (MEN) types 2A and 2B and …

Double germline mutations in the RET Proto-oncogene in MEN 2A and MEN 2B kindreds

S Dvorakova, E Vaclavikova, A Ryska… - Experimental and …, 2006 - thieme-connect.com
Medullary thyroid carcinoma (MTC) is a rare form of thyroid cancer representing about 10%
of all thyroid malignancies. It occurs mostly as a sporadic tumor or in association with …