The effect of short term administration of flutamide on the hypothalamic-pituitary-gonadal
axis was studied in six patients with advanced prostate cancer (C2 stage). Flutamide …

The phase II study of flutamide, a pure anti-androgen, was performed to estimate the clinical
doses on 165 hormone untreated or treated patients with prostatic cancer. The hormone …

A prior comparison of 750 mg flutamide daily to 500 mg daily with an LHRH analog or
orchiectomy showed no difference in effect on prostate specific antigen (PSA). However, any …

Synopsis Flutamide is a non-steroidal antiandrogenic drug devoid of hormonal agonist
activity. Flutamide appears to be a specific antiandrogen only at androgen-dependent …

A phase I study of orally administered flutamide (a pure anti-androgen) was performed in 26
patients with prostatic cancer. No side effects were observed in 11 patients receiving single …

The effect of flutamide on basal and ACTH-stimulated plasma levels of adrenal androgens
was investigated in 6 patients with untreated advanced prostate cancer, aged 52–75 yr …

The present study describes a method for the measurement of the plasma levels of hydroxy‐
flutamide (Flu‐OH), the biologically active and main circulating metabolite of flutamide. We …

Although treatment of intact adult male rats with the pure antiandrogen flutamide or a
luteinizing hormone‐releasing hormone (LHRH) agonist alone leads to partial inhibition of …

Flutamide is a nonsteroidal antiandrogen used in the treatment of prostatic carcinoma. We
have investigated the disposition of flutamide and its two major metabolites in ten urological …

Synopsis Flutamide, a nonsteroidal antiandrogenic drug devoid of hormonal agonist activity,
is used in the treatment of advanced prostate cancer. In previously untreated patients …