[HTML][HTML] microRNA-363-3p reduces endothelial cell inflammatory responses in coronary heart disease via inactivation of the NOX4-dependent p38 MAPK axis

T Zhou, S Li, L Yang, D Xiang - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Coronary heart disease (CHD) is one of the leading causes of heart-associated deaths
worldwide. This study aimed to investigate the mechanism by which microRNA-363-3p (miR …

MiR-21 confers resistance against CVB3-induced myocarditis by inhibiting PDCD4-mediated apoptosis

J He, Y Yue, C Dong, S Xiong - Clinical and Investigative Medicine, 2013 - utpjournals.press
Purpose The participation of microRNAs (miRNAs) in cardiovascular diseases suggests
them as potential targets for novel preventive and therapeutic strategies. In this study, the …

Long non-coding RNA KCNQ1OT1 increases the expression of PDCD4 by targeting miR-181a-5p, contributing to cardiomyocyte apoptosis in diabetic cardiomyopathy

SF Zhao, YX Ye, JD Xu, Y He, DW Zhang, ZY Xia… - Acta Diabetologica, 2021 - Springer
Aims Diabetic cardiomyopathy (DCM) is a specific myocardial alteration in patients with
diabetics. LncRNA KCNQ1OT1 has been previously demonstrated to be involved in various …

Protective effects of microrna-22 against endothelial cell injury by targeting NLRP3 through suppression of the inflammasome signaling pathway in a rat model of …

WQ Huang, P Wei, RQ Lin, F Huang - Cellular Physiology and …, 2017 - karger.com
Background/Aims: This study aimed to identify the role of microRNA-22 (miR-22) in
endothelial cell (EC) injury in coronary heart disease (CHD) by targeting NLRP3 through the …

Downregulation of microRNA-182 inhibits cell growth and invasion by targeting programmed cell death 4 in human lung adenocarcinoma cells

M Wang, Y Wang, W Zang, H Wang, H Chu, P Li, M Li… - Tumor Biology, 2014 - Springer
Lung cancer is a major cause of cancer death worldwide. Programmed cell death 4
(PDCD4), an important tumor suppressor, influences transcription and translation of multiple …

Suppression of miR-127 protects PC-12 cells from LPS-induced inflammatory injury by downregulation of PDCD4

Z Zhang, F Wan, Q Zhuang, Y Zhang, Z Xu - Biomedicine & …, 2017 - Elsevier
Spinal cord injury (SCI) is one of the most debilitating injuries. Inflammatory response plays
a central role in regulating the pathogenesis of acute and chronic SCI. Our study explores …

MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis

Y Xue, Z Wei, H Ding, Q Wang, Z Zhou, S Zheng… - Atherosclerosis, 2015 - Elsevier
Background Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a
master regulator of cellular energy metabolism that is associated with many cardiovascular …

MicroRNA-182 modulates chemosensitivity of human non-small cell lung cancer to cisplatin by targeting PDCD4

F Ning, F Wang, M Li, Z Yu, Y Hao, S Chen - Diagnostic pathology, 2014 - Springer
Abstract Background Overexpression of microRNA-182 (miR-182) is found in various human
cancers, including non-small cell lung cancer (NSCLC). Our aim is to investigate the …

miR‑590‑5p may regulate colorectal cancer cell viability and migration by targeting PDCD4

T Guo, J Wang, G Cheng… - Experimental and …, 2020 - spandidos-publications.com
Recent studies have revealed that microRNAs (miRs) are involved in the pathogenesis of
colorectal cancer (CRC); however, the roles of miR‑590‑5p in CRC are not completely …

[HTML][HTML] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor PDCD4 and promotes cell transformation, proliferation, and metastasis in renal …

X Li, S Xin, Z He, X Che, J Wang, X Xiao… - Cellular Physiology and …, 2014 - karger.com
Objectives: MiR-21 induces neoplastic transformation, cell proliferation, and metastasis and
downregulates programmed cell death4 (PDCD4) in some cancers. The aim of this study …