The integrity of the blood-brain barrier may play an important pathophysiological role during
postischemic reperfusion. To determine the factors that lead to exacerbation of brain injury …

We describe a new focal ischemia model consisting of unilateral middle cerebral artery
occlusion with a silicone rubber cylinder attached to a nylon surgical thread inserted through …

✓ A new model for establishing a successful and consistent arterial recirculation has been
devised following middle cerebral artery (MCA) occlusion in the rat. A snare ligature was …

By means of magnetic resonance imaging (MRI) we longitudinally monitored the evolution of
ischemic injury, changes in cerebral hemodynamics and alterations of the blood–brain …

A sensitive quantitative fluorescence method was used to explore the time course and
regional pattern of blood-brain barrier (BBB) opening after transient middle cerebral artery …

In this study we explored if the secondary bioenergetic failure, which occurs a few hours
after recirculation, following transient middle cerebral artery occlusion (MCAO) in rats, is …

Cerebral infarction was produced in rats by a combination of transient unilateral common
carotid artery occlusion and systemic hypoxia. Horseradish peroxidase (HRP) and Evans …

It has been reported recently that very delayed damage can occur as a result of focal
cerebral ischemia induced by vascular occlusion of short duration. With use of diffusion-, T2 …

Objective: Tracer constants (Ki) for blood-to-brain diffusion of sucrose were measured in the
rat to profile the time course of blood-brain barrier injury after temporary focal ischemia, and …

Background and Purpose Because in humans the clinical benefits of reperfusion remain
controversial, it is important to determine whether reperfusion per se reduces infarct volume …