Interferon-γ and atherosclerosis: pro-or anti-atherogenic?

EJ Harvey, DP Ramji - Cardiovascular research, 2005 - academic.oup.com
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex
network of inter-and intra-cellular signaling pathways. The pleiotropic cytokine interferon-γ …

Atherosclerosis and interferon-γ: new insights and therapeutic targets

I Voloshyna, MJ Littlefield, AB Reiss - Trends in cardiovascular medicine, 2014 - Elsevier
Atherosclerosis is considered to be a chronic inflammatory disease of the arterial wall.
Atherogenesis is accompanied by local production and release of inflammatory mediators …

Interferon gamma: a master regulator of atherosclerosis

JE McLaren, DP Ramji - Cytokine & growth factor reviews, 2009 - Elsevier
Atherosclerosis is a chronic inflammatory disease that is characterized by the development
of fibrotic plaques in the arterial wall. The disease exhibits a complex aetiology and its …

The role of interferon-γ in cardiovascular disease: An update

A Elyasi, I Voloshyna, S Ahmed, LJ Kasselman… - Inflammation …, 2020 - Springer
Purpose Cardiovascular disease (CVD) is the leading cause of death, globally, and its
prevalence is only expected to rise due to the increasing incidence of co-morbidities such as …

[HTML][HTML] Interferon-γ: Promising therapeutic target in atherosclerosis

JWE Moss, DP Ramji - World journal of experimental medicine, 2015 - ncbi.nlm.nih.gov
Atherosclerosis is a chronic inflammatory disorder of the vasculature and is the primary
cause of cardiovascular disease (CVD). CVD is currently the world's leading cause of death …

[PDF][PDF] Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions

P Goossens, MJJ Gijbels, A Zernecke, W Eijgelaar… - Cell metabolism, 2010 - cell.com
Inflammatory cytokines are well-recognized mediators of atherosclerosis. Depending on the
pathological context, type I interferons (IFNs; IFNα and IFNβ) exert either pro-or anti …

Interferons as essential modulators of atherosclerosis

MCS Boshuizen, MPJ de Winther - … , thrombosis, and vascular …, 2015 - Am Heart Assoc
Interferons (IFNs) are key regulators of both innate and adaptive immune responses. The
family of IFN cytokines can be divided into 3 main subtypes of which type I and type II IFNs …

Gamma interferon: a central mediator in atherosclerosis

MLA Leon, SH Zuckerman - Inflammation research, 2005 - Springer
Atherosclerosis is a chronic inflammatory disease of the vasculature with lesions developing
in the arterial wall, frequently in the coronary and carotid arteries. The interaction between …

Cytokines in the pathogenesis of atherosclerosis

JL Young, P Libby, U Schönbeck - Thrombosis and …, 2002 - thieme-connect.com
Research during the last two decades established atheromatous lesions as active sites of
inflammation and immune responses, contrasting to the traditional view of atherosclerosis as …

Type-I interferons in atherosclerosis

HJ Chen, SW Tas, MPJ De Winther - Journal of Experimental Medicine, 2019 - rupress.org
The contribution of dyslipidemia and inflammation in atherosclerosis is well established.
Along with effective lipid-lowering treatments, the recent success of clinical trials with anti …