CYP2C19 polymorphisms in the Thai population and the clinical response to clopidogrel in patients with atherothrombotic-risk factors
C Sukasem, R Tunthong, M Chamnanphon… - Pharmacogenomics …, 2013 - Taylor & Francis
Genetic variation in the cytochrome P450 2C19 (CYP2C19) gene has been documented
gradually as the determinant conversion and variability in the antiplatelet effect of …
gradually as the determinant conversion and variability in the antiplatelet effect of …
Genetic polymorphisms of CYP2C19 influences the response to clopidogrel in ischemic heart disease patients in the South Indian Tamilian population
K Subraja, SA Dkhar, R Priyadharsini… - European journal of …, 2013 - Springer
Background The antiplatelet activity of clopidogrel is variable among patients suffering from
ischemic heart disease. Variation in the cytochrome P450 2C19 (CYP2C19) gene coding for …
ischemic heart disease. Variation in the cytochrome P450 2C19 (CYP2C19) gene coding for …
Influence of CYP2C19 loss‐of‐function variants on the metabolism of clopidogrel in patients from north‐western China
What is known and objective Variation of the cytochrome P450 2C19 gene coding for the
CYP 2C19 enzyme has been reported to be associated with clopidogrel response variability …
CYP 2C19 enzyme has been reported to be associated with clopidogrel response variability …
Effects of CYP2C19 genetic polymorphisms on the pharmacokinetic and pharmacodynamic properties of clopidogrel and its active metabolite in healthy Chinese …
BL Song, M Wan, D Tang, C Sun, YB Zhu, N Linda… - Clinical Therapeutics, 2018 - Elsevier
Purpose Some studies in the white population have shown that carriers of at least 1 loss-of-
function allele in the gene that encodes the cytochrome P-450 2C19 isozyme (CYP2C19) …
function allele in the gene that encodes the cytochrome P-450 2C19 isozyme (CYP2C19) …
Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan
T Jinnai, H Horiuchi, T Makiyama, J Tazaki… - Circulation …, 2009 - jstage.jst.go.jp
Background: The P2Y 12 adenosine diphosphate (ADP) receptor blocker, clopidogrel, an
essential drug for the prevention of stent thrombosis after percutaneous coronary …
essential drug for the prevention of stent thrombosis after percutaneous coronary …
[HTML][HTML] The CYP2C19* 17 variant is not independently associated with clopidogrel response
JP Lewis, SH Stephens, RB Horenstein… - Journal of Thrombosis …, 2013 - Elsevier
Summary Background Cytochrome P450 2C19 (CYP2C19) is the principal enzyme
responsible for converting clopidogrel into its active metabolite, and common genetic …
responsible for converting clopidogrel into its active metabolite, and common genetic …
Cytochrome P450 2C19* 2 polymorphism and cardiovascular recurrences in patients taking clopidogrel: a meta-analysis
Several polymorphisms in genes that encode platelet components (receptors or enzymes),
or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been …
or cytochrome P450 enzyme isoforms, involved in clopidogrel metabolism, have been …
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
AR Shuldiner, JR O'Connell, KP Bliden, A Gandhi… - Jama, 2009 - jamanetwork.com
Context Clopidogrel therapy improves cardiovascular outcomes in patients with acute
coronary syndromes and following percutaneous coronary intervention by inhibiting …
coronary syndromes and following percutaneous coronary intervention by inhibiting …
Cytochrome P450 2C19 polymorphism is associated with poor clinical outcomes in coronary artery disease patients treated with clopidogrel
B Jin, HC Ni, W Shen, J Li, HM Shi, Y Li - Molecular biology reports, 2011 - Springer
Patients with lesser degrees of platelet inhibition in response to clopidogrel appear to be at
increased risk for recurrent ischemic events. Cytochrome P450 (CYP) polymorphisms have …
increased risk for recurrent ischemic events. Cytochrome P450 (CYP) polymorphisms have …
Prevalence of CYP2C19 polymorphisms in the Lebanese population
I Djaffar Jureidini, N Chamseddine, S Keleshian… - Molecular biology …, 2011 - Springer
Clopidogrel is one of the most commonly prescribed drugs, as its combination with low-dose
aspirin is the recommended oral anti-platelet therapy, to prevent ischaemic events following …
aspirin is the recommended oral anti-platelet therapy, to prevent ischaemic events following …