Organoid models allow for the study of key pathophysiological processes such as cancer
biology in vitro. They offer insights into all aspects covering tumor development, progression …

Patient-derived pancreatic ductal adenocarcinoma (PDAC) organoid systems show great
promise for understanding the biological underpinnings of disease and advancing …

Pancreatic cancer carries a terrible prognosis, as the fourth most common cause of cancer
death in the Western world. There is clearly a need for new therapies to treat this disease …

Tumor models have created new avenues for personalized medicine and drug
development. A new culture model derived from a three-dimensional system, the tumor …

Background Patient-derived tumor models are the new standard for pre-clinical drug testing
and biomarker discovery. However, the emerging technology of primary pancreatic cancer …

Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …

Gastrointestinal (GI) cancers constitute the largest portion of all human cancers and
represent a significant health burden on modern society. Conventional therapeutic …

Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the
third leading cause of cancer-related mortality in the United States. Although important …

Organoid cultures have emerged as powerful model systems accelerating discoveries in
cellular and cancer biology. These three-dimensional cultures are amenable to diverse …

Cancer organoids, a three‐dimensional (3D) culture system of cancer cells derived from
tumor tissues, recapitulate physiological structure of the parental tumor. Different tumor …