Separate measurement of plasma levels of acylated and desacyl ghrelin in healthy subjects using a new direct ELISA assay
T Akamizu, T Shinomiya, T Irako… - The Journal of …, 2005 - academic.oup.com
Two forms of ghrelin, acylated and desacyl, circulate in plasma. Although acylation is
thought to be essential for ghrelin biological activities, recent studies have suggested that …
thought to be essential for ghrelin biological activities, recent studies have suggested that …
Characterization of ghrelin-like immunoreactivity in human plasma
M Patterson, KG Murphy, CW le Roux… - The Journal of …, 2005 - academic.oup.com
Ghrelin is a gastric peptide hormone that has an important role in appetite control and GH
release. Circulating ghrelin levels are inversely correlated with body mass index and …
release. Circulating ghrelin levels are inversely correlated with body mass index and …
Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa
M Hotta, R Ohwada, H Katakami… - The Journal of …, 2004 - academic.oup.com
Abstract Octanoylated ghrelin (1–28)(intact ghrelin) is rapidly and easily degraded to
desoctanoyl forms or smaller fragments (degraded ghrelin). Plasma levels of intact and …
desoctanoyl forms or smaller fragments (degraded ghrelin). Plasma levels of intact and …
Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
H Ariyasu, K Takaya, T Tagami, Y Ogawa… - The Journal of …, 2001 - academic.oup.com
Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat
stomach and is involved in a novel system for regulating GH release. Although previous …
stomach and is involved in a novel system for regulating GH release. Although previous …
Optimum collection and storage conditions for ghrelin measurements: octanoyl modification of ghrelin is rapidly hydrolyzed to desacyl ghrelin in blood samples
H Hosoda, K Doi, N Nagaya, H Okumura… - Clinical …, 2004 - academic.oup.com
Ghrelin is an acylated peptide with growth-hormonereleasing activity (1). It was first isolated
from rat and human stomach during the search for an endogenous ligand to the “orphan” G …
from rat and human stomach during the search for an endogenous ligand to the “orphan” G …
Differential responses of circulating ghrelin to high-fat or high-carbohydrate meal in healthy women
P Monteleone, R Bencivenga… - The Journal of …, 2003 - academic.oup.com
The effects of specific nutritional factors on ghrelin secretion have not been investigated in
humans. Therefore, we assessed ghrelin responses to a high-carbohydrate meal (1217 kcal …
humans. Therefore, we assessed ghrelin responses to a high-carbohydrate meal (1217 kcal …
Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men
J Liu, CE Prudom, R Nass, SS Pezzoli… - The Journal of …, 2008 - academic.oup.com
Context: Ghrelin, an acylated peptide hormone secreted from the gut, regulates appetite and
metabolism. Elucidating its pattern of secretion in the fed and fasted states is important in the …
metabolism. Elucidating its pattern of secretion in the fed and fasted states is important in the …
The relationship between active ghrelin levels and human obesity involves alterations in resting energy expenditure
P Marzullo, B Verti, G Savia, GE Walker… - The Journal of …, 2004 - academic.oup.com
Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation.
Ser (3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although …
Ser (3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although …
Plasma levels of active form of ghrelin during oral glucose tolerance test in patients with anorexia nervosa
Y Nakai, H Hosoda, K Nin, C Ooya… - European journal of …, 2003 - academic.oup.com
Objective Ghrelin is an acylated peptide, whose octanoyl modification is essential for its
biological activities. Previous studies demonstrated that fasting plasma ghrelin levels were …
biological activities. Previous studies demonstrated that fasting plasma ghrelin levels were …
Non-acylated ghrelin does not possess the pituitaric and pancreatic endocrine activity of acylated ghrelin in humans
F Broglio, A Benso, C Gottero, F Prodam… - Journal of …, 2003 - Springer
Ghrelin, a 28-amino acid peptide predominantly produced by the stomach, displays strong
GH-releasing activity mediated by the GH secretagogue (GHS)-receptor (GHS-R) type 1a at …
GH-releasing activity mediated by the GH secretagogue (GHS)-receptor (GHS-R) type 1a at …