Polycationic polyamines are present in nearly all living organisms and are essential for
mammalian cell growth and survival, and for development. These positively charged …

In addition to polyamine homoeostasis, it has become increasingly clear that polyamine
catabolism can play a dominant role in drug response, apoptosis and the response to …

Polyamines are essential for the growth and function of normal cells. They interact with
various macromolecules, both electrostatically and covalently and, as a consequence, have …

The chemically simple, biologically complex eukaryotic polyamines, spermidine and
spermine, are positively charged alkylamines involved in many crucial cellular processes …

Biosynthesis of the polyamines spermidine and spermine and their precursor putrescine is
controlled by the activity of the two key enzymes ornithine decarboxylase (ODC) and S …

Polyamines are well-known ubiquitous components of living cells. Although these
polycations have been implicated in the regulation of major cellular functions such as DNA …

The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately
involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects …

The polyamines spermidine, spermine, and their precursor putrescine are essential for cell
growth and the regulation of the cell cycle. Recent studies suggest that excessive …

Maintenance of intestinal epithelial integrity requires cellular polyamines that regulate
expression of various genes involved in cell proliferation, growth arrest and apoptosis. In …

Ageing results from complex genetically and epigenetically programmed processes that are
elicited in part by noxious or stressful events that cause programmed cell death. Here, we …