Recent studies suggest that overexpression of the polyamine-acetylating enzyme
spermidine/spermine N 1-acetyltransferase (SSAT) significantly increases metabolic flux …

The immune system is remarkably responsive to a myriad of invading microorganisms and
provides continuous surveillance against tissue damage and developing tumor cells. To …

Polyamines are small aliphatic polycations present in all living cells. Polyamines are
essential for cellular viability and are involved in regulating fundamental cellular processes …

Apoptosis plays a critical role in the maintenance of gut mucosal homeostasis and is
regulated by numerous factors including polyamines. Although the exact roles of polyamines …

The polyamines spermine, spermidine, and putrescine are small organic molecules one or
more of which are present in all living organisms. Many natural products contain polyamine …

Alpha-difluoromethylornithine (DFMO) inhibits the proto-oncogene ornithine decarboxylase
(ODC) and is known to induce cell cycle arrest. However, the effect of DFMO on human …

Polyamines are organic polycations that bind to a variety of cellular molecules, including
nucleic acids. Within cells, polyamines contribute to both the efficiency and fidelity of protein …

All mammalian cells depend on polyamines for normal growth and proliferation, but the
exact roles of polyamines at the molecular level remain largely unknown. The RNA-binding …

The polyamines are small basic molecules essential for cellular proliferation and viability. An
autoregulatory circuit that responds to the intracellular level of polyamines regulates their …

Most tumors maintain elevated levels of polyamines to support their growth and survival.
This study explores the anti-tumor effect of polyamine starvation via both inhibiting …