A comprehensive, state-of-the-art review of our current understanding of the molecular and
structural biology of 5-HT receptors and their potential use for drug discovery. The authors …

Serotonin (5-hydroxytryptamine, 5-HT) is probably unique among the monoamines in that its
effects are subserved by as many as 13 distinct heptahelical, G-protein-coupled receptors …

Like most neurotransmitters, serotonin possesses a simple structure. However, the
pharmacological consequences are more complex and diverse. Serotonin is involved in …

Central serotonin (5-hydroxytryptamine, 5-HT) systems regulate a wide variety of complex
behaviors, and are targeted by drugs used in the treatment of diverse neuropsychiatric …

Since its discovery, serotonin (5-hydroxytryptamine= 5-HT) has become a major player on
the neurotransmitter" stage". Multiple receptor subtypes for 5-HT have been identified and …

5-hydroxytryptamine2A (5-HT2A) serotonin receptors are important pharmacological targets
for a large number of central nervous system and peripheral serotonergic medications. In …

Abstract Serotonin (5-hydroxytryptamine; 5-HT), along with its receptors, is one of the oldest
molecular devices assuming intercellular communication, being present as soon as simple …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

Within the family of serotonin receptors, the 5-hydroxytryptamine-3 (5-HT3) receptor is the
only ligand-gated ion channel. It is composed of five subunits, of which the 5-HT3A and 5 …

Since the 1950s, when serotonin (5-HT) was discovered in the mammalian central nervous
system (CNS), an enormous amount of experimental evidence has revealed the pivotal role …