The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue
regeneration and an appealing therapeutic target. However, its clinical exploitation is …

Developmental stage-specific differentiation of stem or progenitor cells into safe and
functional cells is of fundamental importance in regenerative medicine, including β-cell …

Abstract α-cells, which synthesize glucagon, also support β-cell survival and have the
capacity to transdifferentiate into β-cells. However, the role of α-cells in pathological …

Beta-cell deficit is the major pathological feature in type 1 and type 2 diabetes patients, and
plays a key role in disease progression. In principle, beta-cell regeneration can occur by …

Type 1 diabetes is a metabolic disease resulting in the selective loss of pancreatic insulin-
producing β-cells and affecting millions of people worldwide. The side effects of diabetes are …

Diabetes is caused by insufficient insulin secretion due to β-cell dysfunction and/or β-cell
loss. Therefore, the restoration of functional β-cells by the induction of β-cell differentiation …

Whether facultative β cell progenitors exist in the adult pancreas is a major unsolved
question. To date, lineage-tracing studies have provided conflicting results. To track β cell …

Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However,
spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging …

Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of beta
cells by immune cells. The interactions among cells within the islets may be closely linked to …

Current differentiation protocols have not been successful in reproducibly generating fully
functional human beta cells in vitro, partly due to incomplete understanding of human …