The applications of human pluripotent stem cell (hPSC)-derived cells in regenerative
medicine has encountered a long-standing challenge: how can we efficiently obtain mature …

Conversion of one terminally differentiated cell type into another (or transdifferentiation)
usually requires the forced expression of key transcription factors. We examined the …

Abstract Knowledge of the pathways involved in islet cell differentiation has been exploited
to develop new methods for generating beta cells from non-beta cells, such as embryonic …

Pancreatic insulin-secreting β-cells are essential regulators of glucose metabolism. New
strategies are currently being investigated to create insulin-producing β cells to replace …

Most studies in type 1 diabetes (T1D) have focused on the loss of the pancreatic beta-cell
population. However, despite the involvement of the alpha-cell in the aetiology and …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Background In both humans and rodents, glucose homeostasis is controlled by micro-
organs called islets of Langerhans composed of beta cells, associated with other endocrine …

Aims/hypothesis Fetal and neonatal beta cells have poor glucose-induced insulin secretion
and only gain robust glucose responsiveness several weeks after birth. We hypothesise that …

Understanding how pancreatic β cells achieve and maintain functional identity as insulin-
secreting cells is a major roadblock in our understanding of the aetiology of diabetes …

Background Insulin producing beta cell and glucagon producing alpha cells are colocalized
in pancreatic islets in an arrangement that facilitates the coordinated release of the two …