Diabetes occurs when the pancreas fails to pro-duce and secrete sufficient insulin for the
maintenance of glucose homeostasis. Although many factors required for β-cell …

The production of insulin-producing β cells from human embryonic stem cells (hESCs) in
vitro represents a promising strategy for a cell-based therapy for type 1 diabetes mellitus. To …

Understanding distinct gene expression patterns of normal adult and developing fetal
human pancreatic α-and β-cells is crucial for developing stem cell therapies, islet …

The in vitro differentiation of insulin-producing beta-like cells can model aspects of human
pancreatic development. Here, we generate 95,308 single-cell transcriptomes and …

OBJECTIVE—To document the transcriptome of the pancreatic islet during the early and late
development of the mouse pancreas and highlight the qualitative and quantitative features …

Ductal cells have been proposed as a source of adult β cell neogenesis, but this has
remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA …

Generation of mature pancreatic β-cells from embryonic stem (ES) cells in vitro could
provide a therapy for insulin-dependent diabetes mellitus. Recent ES cell differentiation …

Understanding in detail how pancreatic endocrine cells develop is important for many
reasons. From a scientific point of view, elucidation of such a complex process is a major …

During the pathogenesis of type 1 diabetes (T1D) and type 2 diabetes (T2D), pancreatic
islets, especially the β cells, face significant challenges. These insulin-producing cells adopt …

Aims/hypothesis The functional maturity of pancreatic beta cells is impaired in diabetes
mellitus. We sought to define factors that can influence adult beta cell maturation status and …