The emergence of bihormonal (BH) cells expressing insulin and glucagon has been
reported under diabetic conditions in humans and mice. Whereas lineage tracing studies …

In the field of stem cell biology and diabetes, we and others seek to derive mature and
functional human pancreatic β cells for disease modeling and cell replacement therapy …

Characterization of endocrine-cell functions and associated molecular signatures in
diabetes is crucial to better understand why and by which mechanisms alpha and beta cells …

Human pancreatic islets engrafted into immunodeficient mice serve as an important model
for in vivo human diabetes studies. Following engraftment, islet function can be monitored in …

As one of the key nutrient sensors, insulin signaling plays an important role in integrating
environmental energy cues with organism growth. In adult organisms, relative insufficiency …

Pancreatic β-cell dysfunction and reduced insulin secretion play a key role in the
pathogenesis of diabetes. Fetal and neonatal islets are functionally immature and have …

Due to the increasing prevalence of type 1 diabetes and the complications arising from
actual therapies, alternative treatments need to be established. In order to compensate the …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

Pancreatic endocrine cells, which are clustered in islets, regulate blood glucose stability and
energy metabolism. The distinct cell types in islets, including insulin-secreting β cells, are …

Type 1 diabetes is caused by the loss of insulin‐producing β‐cells as a result of an
autoimmune condition. Despite current therapeutic approaches aimed at restoring the …