Diabetes is a multifactorial metabolic disorder defined by the loss of functional pancreatic
insulin-producing β-cells. The functional maturation and dedifferentiation of adult β-cells is …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

During pancreatic development, endocrine cells appear from the pancreatic epithelium
when Neurog3-positive cells delaminate and differentiate into α-, β-, γ-and δ-cells. The …

The alpha cells that co-occupy the islets in association with beta cells have been long
recognized as the source of glucagon, a hyperglycemia-producing and diabetogenic …

Insulin injections treat but do not cure Type 1 diabetes (T1DM). The success of islet
transplantation suggests cell replacement therapies may offer a curative strategy. However …

Embryonic stem (ES) cell technology may serve as a platform for the discovery of drugs to
treat diseases such as diabetes. However, because of difficulties in establishing reliable ES …

Directed differentiation of human pluripotent stem cells into functional insulin‐producing
beta‐like cells holds great promise for cell replacement therapy for patients suffering from …

Understanding the mechanisms that underlie the generation and regeneration of β cells is
crucial for developing treatments for diabetes. However, traditional research methods, which …

It has been suggested that new beta cells can arise from specific populations of adult
pancreatic progenitors or facultative stem cells. However, their existence remains …

Objective Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing
functions in regulating plasma glucose levels, the two cell types share a common …