The importance of mesenchymal-epithelial interactions for normal development of the
pancreas was recognized in the early 1960s, and mesenchymal signals have been shown …

The adult pancreatic ductal system was suggested to harbor facultative beta-cell progenitors
similar to the embryonic pancreas, and the appearance of insulin-positive duct cells has …

Through the analysis of genetically modified mice a hierarchy of transcription factors
regulating pancreas specification, endocrine destiny as well as endocrine subtype …

By virtue of their capability to replicate and regenerate, human stem-cell-derived beta-like
cells could be a valuable resource for cellular therapy targeting insulin-dependent diabetes …

Aim Poorly controlled diabetes is characterised by a partial or complete loss of pancreatic
islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble …

Diabetes mellitus represents a major healthcare burden and, due to the increasing
prevalence of type I diabetes and the complications arising from current treatments, other …

Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the
development of alternate durable treatments a priority. The ability of the pancreas to …

The pancreatic islet is a mini-organ that consists of several hormone-secreting endocrine
cell types in adults. Islets execute a vital physiological function in regulating glucose …

Insulin-producing cells derived from embryonic stem cells could be surrogates for beta cells
in diabetes therapy. However, their derivation remains hard to achieve with current protocols …

A key therapeutic approach for the treatment of Type 1 diabetes (T1D) is transplantation of
functional islet β-cells. Despite recent advances in generating stem cell-derived glucose …