Transcriptional and functional cellular specialization has been described for insulin-
secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell …

Immature pancreatic β-cells are highly proliferative, and the expansion of β-cells during the
early neonatal period largely determines functional β-cell mass; however, the mechanisms …

Diabetes, particularly type 1 diabetes, results from the lack of pancreatic β-cells. β-cell
replenishment can functionally reverse diabetes, but two critical challenges face the field: 1 …

In this issue of Cell Stem Cell, Gribben et al.(2021), using improved lineage-tracing mice
and longer chase times, have provided clear evidence of new islet cells forming from the …

Diabetic patients exhibit a reduction in β cells, which secrete insulin to help regulate glucose
homeostasis; however, little is known about the factors that regulate proliferation of these …

Reliance on rodents for understanding pancreatic genetics, development and islet function
could limit progress in developing interventions for human diseases such as diabetes …

Background Pregnancy represents a major metabolic challenge for the mother, and involves
a compensatory response of the pancreatic beta-cell to maintain normoglycemia. However …

Insulin-secreting pancreatic β-cells are essential regulators of mammalian metabolism. The
absence of functional β-cells leads to hyperglycemia and diabetes, making patients …

Understanding and manipulating pancreatic β-cell proliferation is a major challenge for
pancreas biology and diabetes therapy. Recent studies have raised the possibility that …

Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting
insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In …