Human embryonic stem cells (hESCs) are a potential unlimited source of insulin-producing
β cells for diabetes treatment. A greater understanding of how β cells form during embryonic …

Diabetes is an epidemic with increasing incidence across the world. Most individuals who
are afflicted by this disease have type 2 diabetes, but there are many who suffer from type 1 …

Human embryonic stem cell (hESC)-derived pancreatic alpha and beta cells can be used to
develop cell replacement therapies to treat diabetes. However, recent published …

Following differentiation during fetal development, β cells further adapt to their postnatal role
through functional maturation. While adult islets are thought to contain functionally mature β …

To develop methods for the generation of insulin-producing β-cells for the treatment of
diabetes, we have used GFP-tagged embryonic stem cells (ESCs) to elucidate the process …

In diabetes mellitus, insulin-producing beta cells in the pancreas are lost (type 1) or
dysfunctional (type 2). Cell replacement therapy has emerged as a promising alternative to …

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Abstract Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic
glucose levels. Emerging evidence suggests that islet cells are functionally heterogeneous …

Insulin-secreting pancreatic beta cells play a key role in the pathogenesis of diabetes
mellitus. Potential new treatments for this disease include cell-replacement therapies using …

Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …