Cellular progenitors remain poorly characterized in many adult tissues, limited in part by the
lack of unbiased techniques to identify progenitors and their progeny. To address this …

Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing
α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it …

Pancreatic β-cells are critical regulators of glucose homeostasis, and they vary dramatically
in their glucose stimulated metabolic response and levels of insulin secretion. It is unclear …

The Department of Obstetrics & Gynecology at the Affiliated Hospital of Xuzhou Medical
College, Jiangsu 221006, China abstract. Strategies for increasing functional beta cell mass …

Islet transplantation from organ donors can considerably improve glucose homeostasis and
well‐being in individuals with type 1 diabetes, where the beta cells are destroyed by the …

Decoding the molecular composition of individual Ngn3+ endocrine progenitors (EPs)
during pancreatic morphogenesis could provide insight into the mechanisms regulating …

Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-
cells in the pancreas, resulting in failure of blood glucose regulation and devastating …

The existence of adult β-cell progenitors remains the most controversial developmental
biology topic in diabetes research. It has been reported that β-cell progenitors can be …

Glucose homeostasis greatly depends on the match between fluctuating insulin demands
and adjusted rates of insulin secretion, which is the function of pancreatic beta cells …

The pancreas is composed of two main compartments consisting of endocrine and exocrine
tissues. The majority of the organ is exocrine and responsible for the synthesis of digestive …