An acellular scaffold facilitates endometrial regeneration and fertility restoration via recruiting endogenous mesenchymal stem cells

L Xin, X Zheng, J Chen, S Hu, Y Luo… - Advanced …, 2022 - Wiley Online Library
Severe intrauterine adhesions (IUAs), characterized by inadequate endometrial repair and
fibrosis, can lead to infertility. Stem cell‐based therapies, which deliver mesenchymal stem …

A construct of adipose-derived mesenchymal stem cells—laden collagen scaffold for fertility restoration by inhibiting fibrosis in a rat model of endometrial injury

Y Dai, L Xin, S Hu, S Xu, D Huang, X Jin… - Regenerative …, 2023 - academic.oup.com
Severe endometrium damage causes pathological conditions such as thin endometrium and
intrauterine adhesion, resulting in uterine factor infertility. Mesenchymal stem cell (MSC) …

A collagen scaffold loaded with human umbilical cord-derived mesenchymal stem cells facilitates endometrial regeneration and restores fertility

L Xin, X Lin, Y Pan, X Zheng, L Shi, Y Zhang, L Ma… - Acta biomaterialia, 2019 - Elsevier
In women of reproductive age, severe injuries to the endometrium are often accompanied by
endometrial scar formation or intrauterine adhesions (IUAs), which can result in infertility or …

A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage …

L Xin, X Lin, F Zhou, C Li, X Wang, H Yu, Y Pan, H Fei… - Acta biomaterialia, 2020 - Elsevier
Endometrial traumas may cause intrauterine adhesions (IUAs), leading to infertility.
Conventional methods in clinic have not solved the problem of endometrial regeneration in …

[HTML][HTML] Recent developments in bio-scaffold materials as delivery strategies for therapeutics for endometrium regeneration

X Li, HF Lv, R Zhao, M Ying, AT Samuriwo, YZ Zhao - Materials Today Bio, 2021 - Elsevier
Intrauterine adhesions (IUAs) refer to the repair disorder after endometrial injury and may
lead to uterine infertility, recurrent miscarriage, abnormal menstrual bleeding, and other …

[HTML][HTML] Making more womb: clinical perspectives supporting the development and utilization of mesenchymal stem cell therapy for endometrial regeneration and …

M Strug, L Aghajanova - Journal of Personalized Medicine, 2021 - mdpi.com
The uterus is a homeostatic organ, unwavering in the setting of monthly endometrial
turnover, placental invasion, and parturition. In response to ovarian steroid hormones, the …

Synergistic regenerative effects of functionalized endometrial stromal cells with hyaluronic acid hydrogel in a murine model of uterine damage

YY Kim, KH Park, YJ Kim, MS Kim, HC Liu… - Acta Biomaterialia, 2019 - Elsevier
Clinically intractable infertility and recurrent miscarriage due to irreversible endometrial
damage need to be treated with biomaterial-and cell-based therapies. Some previous …

Injectable mesenchymal stem cell‐laden matrigel microspheres for endometrium repair and regeneration

B Xu, Y Cao, Z Zheng, EA Galan, Z Hu, J Ge… - Advanced …, 2021 - Wiley Online Library
Endometrial injury and intrauterine adhesions are increasingly reported in recent years;
however, treatment options remain limited. Intravenous injection of mesenchymal stem cells …

Sodium alginate hydrogel integrated with type III collagen and mesenchymal stem cell to promote endometrium regeneration and fertility restoration

Q Shuai, Y Liang, X Xu, Z Halbiyat, X Wang… - International Journal of …, 2023 - Elsevier
A thinner endometrium has been linked to implantation failure, and various therapeutic
strategies have been attempted to improve endometrial regeneration, including the use of …

[HTML][HTML] Stem cells implanted with nanofibrous mats for injured endometrial regeneration and immune-microenvironment remodeling

L Zhou, H Wang, D Shen, J Xiang, N Yu, X He… - Materials Today Bio, 2023 - Elsevier
Severe endometrial injury caused by invasive uterine operation and/or endometritis often
results in intrauterine adhesions (IUAs), which are named Asherman's syndrome (AS) …