EJ Ari~ ns, for the rc,~ eptor etmccpt, once: only a theoretical construct, is now very much
one of the trends in pharmacologk tl thinking. Besides providing a theoretical framework for …

Pharmacology is the science of receptors. This has been appreciated ever since
pharmacology began to emerge as a separate discipline. Langley'and Ehrlich2 proposed …

In an interview'published in 1974, Sir Robert Robinson, questioned about the future
direction of organic chemistry, replied that he thought that among areas which would …

As a consequence of a vigorous effort to develop safer analgesics, a large number of drugs
of diverse chemical structures have been identified which have analgesic activity. Many of …

Receptor Classification Although receptor classifications have often originated from
observations with agonists, there appears to be widespread agreement that the safest …

Studies of the binding of ligands to various putative pharmacologic receptors are entering a
new phase. Over the past decade, sufficient expertise has been developed to measure with …

The study of binding is not an easy task especially because of the difficulty of interpreting the
results in terms of binding on specific receptor sites. The problem is not new; what is new is …

The relative potencies of agonists have been used in the past to classify receptors.. This
could be justified on the basis of ideas and equations deve! oped using the occupancy …

The &air of pharmacology (or mate# ria medica, as it was formerly called) at the University of
Edinburgh has had a long and distinguished history'. The subject was originally combined …