AIM: Hypermethylation of the promoter of the hMLH1 gene, which plays an important role in
mismatch repair during DNA replication, occurs in more than 30% of human gastric cancer …

Cancer is a multi-factorial disease and variation in genetic susceptibility, due to inherited
differences in thecapacity to repair mismatches in the genome, is an important factor in the …

AIM: To investigate CpG methylation and single nucleotide polymorphism (SNP) of a specific
promoter region of hMLH1 in primary gastric carcinoma. METHODS: Primary gastric …

A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as
microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with …

Changes in the pattern of DNA methylation are among the most common alterations
observed in human cancers, such as gastric carcinomas. We analysed in a series of 51 …

Abstract Associations of P16, MGMT, hMLH1 and hMLH2 with gastric cancer and their
relation with MTHFR status in gastric patients who were confirmed with pathological …

To determine whether methylation of the hMLH1 promoter is related to increasing age and
gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric …

Hypermethylation of CpG islands in the promoter region is associated with the silencing of a
variety of tumor suppressor genes. DNA repair genes human Mut L homologue 1 (hMLH1) …

Using methylation‐specific real‐time PCR, we determined the prevalence of aberrant
methylation in the mismatch repair gene hMLH1 and in the recently described HPP1 gene …

We aimed to explore the association between aberrant DNA methylation of the O (6)-
methylguanine-DNA methyltransferase (MGMT) and human mutL homolog 1 (hMLH1) …