Background Hypermethylation of promoters that regulate the expression of DNA repair
genes is associated with gastric carcinoma (GC). Little is known regarding the association …

Results There were 50 (9.6%) high-frequency MSI (MSI-H) cases. The MSI-H gastric
carcinomas were associated with older age, expanding type by Ming's classification …

AIM: To appraise the correlation of mutation and methylation of hMSH1 with microsatellite
instability (MSI) in gastric cancers. METHODS: Mutation of hMLH1 was detected by Two …

The purpose of this study was to determine the genotype and allele frequencies of hMLH1 (-
93G> A and I219V) and hMSH2 (-118T> C and IVS12-6T> C) polymorphisms in patients …

In most sporadic gastric carcinomas, microsatellite instability (MSI) originates from
inactivation of the hMLH1 gene by promoter hypermethylation. However, the methylation …

Mutation of DNA mismatch repair genes has rarely been documented in sporadic gastric
carcinoma with microsatellite instability (MSI). In sporadic colorectal carcinoma, hMLH1 …

The occurrence of malignant neoplasms increases with advancing age. Although aging and
carcinogenesis are basically different processes, they share phenomena such as the …

Although gastric cancer (GC) is highly prevalent in China and is a leading cause of cancer-
related death, major advances in early diagnostic and effective therapeutic strategies have …

Key clinicopathologic features of microsatellite instability–positive (MSI+) gastric cancers
(GCs) are that they tend to be located in the antrum and have an intestinal phenotype and …

Microsatellite instability (MSI) is caused mainly by dysfunction of hMLH1, where aberrant
hypermethylation (HM) of its promoter region is involved. Previously, we suggested that HM …