Helicobacter pylori infection induces aberrant DNA methylation, and methylation levels of
several specific marker genes in gastric mucosa are associated with gastric cancer risk …

Objective: We aimed to evaluate the inactivation of COX-2, HMLH1 and CDKN2A by
promoter methylation and its relationship with the infection by different Helicobacter pylori …

Method: A total of 60 gastric cancer cases were retrieved. DNA was extracted from paired
normal and tumour tissues while MLH1 and MSH2 protein expression as well as H. pylori …

Objective It remains unknown whether individuals with a family history (FH) of gastric cancer
(GC) are associated with aberrant DNA methylation. The aim of this study was to investigate …

Aberrant DNA methylation is deeply involved in human cancers, but its inducers and targets
are still mostly unclear. Helicobacter pylori infection was recently shown to induce aberrant …

BACKGROUND The authors purpose in this study was to clarify the difference in terms of
clinicopathologic features between gastric cancer (GC) with high numbers of DNA …

Microsatellite instability (MSI) and frameshift mutations in the genes containing coding
nucleotide repeats have been reported in a subset of gastric adenomas, however the …

Hypermethylation of the hMLH1 mismatch repair gene promoter has been revealed to lead
to microsatellite instability (MSI). Previously, we demonstrated a high prevalence of MSI in …

Introduction: Risk prediction of gastric cancers is important to implement appropriate
screening procedures. Although aberrant DNA methylation is deeply involved in gastric …

Aim: We carried out a case–control study in an Omani Arab population to investigate the
association between gastric cancer and peripheral blood leukocyte DNA methylation in …