Sporadic gastric cancer is considered to be the result of a progressive accumulation of
genotypic changes due to an adverse environment (ie, diet and Helicobacter pylori …

DNA methyltransferase and DNA demethylase are enzymes potentially affecting promoter
methylation status. We examined levels of DNA methyltransferase (DNMT1, DNMT3a …

Aberrant 5′ CpG island methylation is an alternative mechanism of gene inactivation
during the development of cancer as demonstrated for several tumor‐suppressor genes …

Objective: We aimed to explore the association of P16, MGMT and HMLH1 with gastric
cancer and their relation with Methylenetetrahydrofolate reductase (MTHFR). Methods: 322 …

Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis
occurring in 20% of gastric cancer (GC). However, it is not clear whether MSI phenotype …

Gastric carcinogenesis involves multiple genetic and epigenetic alterations. Epigenetic
silencing of tumor-related genes due to CpG island methylation (CIM) has been recently …

Background: Helicobacter pylori infection potently induces methylation of CpG islands in
gastric mucosae, which is considered to decrease to a certain level after active H. pylori …

Dear Sir: The presence of hundreds of thousands of clonal somatic mutations in simple
repeated sequences characterizes cancer of the microsatellite mutator phenotype (MMP). 1 …

Aims and Background Chronic inflammation leading to malignancy in the esophagus may
be due to errors in mismatch repair (MMR) genes such as hMLH1. Promoter …

AIM: To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes
and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr …