Alterations of multiple oncogenes and tumor suppressor genes, together with genetic
instability, are responsible for carcinogenesis in gastric cancer. The microsatellite mutator …

Dear Sir: The presence of hundreds of thousands of clonal somatic mutations in simple
repeated sequences characterizes cancer of the microsatellite mutator phenotype (MMP). 1 …

Epigenetic events have emerged as key mechanisms in the regulation of critical biological
processes and in the development of a wide variety of human malignancies, including …

Promoter methylation acts as an important alternative to genetic alterations for gene
inactivation in gastric carcinogenesis. Although a number of gastric cancer-associated …

Colorectal cancer (CRC) is caused by a series of genetic or epigenetic changes, and in the
last decade there has been an increased awareness that there are multiple forms of …

Background. Disorders of the DNA repair system that protects against alkylating mutagens
are known to play an important role in carcinogenesis. Methods. We investigated the …

BACKGROUND Transcriptional silencing by CpG‐island hypermethylation now is believed
to be an important mechanism of tumorigenesis. To date, studies on CpG‐island …

Intake of dietary factors that serve as methyl group donors may influence promoter
hypermethylation in colorectal carcinogenesis. We investigated whether dietary folate …

AIM: To evaluate the association between Helicobacter pylori (H. pylori) infection and MLH1
and MGMT methylation and its relationship with microsatellite instability (MSI). METHODS …

Epidemiological studies have indicated that folate metabolism is correlated with increased
risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important …