A number of tumor suppressor and tumor‐related genes are silenced by promoter
hypermethylation in gastric cancer. Hypermethylation is not restricted to cancer cells, but is …

Gastric carcinoma (GC) is one of the human cancers in which promoter CpG island
hypermethylation is frequently found. We used the MethyLight assay to evaluate the …

Changes of DNA methylation in gastric mucosae after eradication of Helicobacter pylori
have not been clarified yet. From this background, we investigated time course of DNA …

Promoter hypermethylation is an alternative mechanism of gene silencing in human cancers
including gastric cancer. While intestinal metaplasia (IM) is generally regarded as a …

Aberrant promoter methylation and subsequent silencing of cancer-related genes has been
recognized as an important pathway involved in gastric carcinogenesis. In fact, several …

Background: Microsatellite instability (MSI) is a form of genetic instability characterized by
new alleles not present in the normal genotype. This mutation occurs by altered DNA …

Background: Although polymorphisms in DNA mismatch repair (MMR) gene MSH2 have
been associated with risks of many cancers, little is known about their etiology role in gastric …

Aberrant DNA methylation is frequently found during gastric carcinogenesis. Recently, we
identified potential methylation markers important for Helicobacter pylori‐induced gastric …

To determine the etiological factors of human colorectal cancer (CRC) we assessed the
frequency and prognostic significance of hMLH1 and hMSH2 genes in conjunction with …

Objectives: Major risk factors of oral squamous cell carcinoma (OSCC) are environmental
and can lead to DNA mutagenesis. Mismatch repair (MMR) system functions to repair small …