The methylation status of seven cancer-related genes was investigated in a series of 58
colorectal cancers, 18 of which showed the microsatellite instability (MSI+) phenotype …

Silencing of tumor suppressor and tumor-related genes by hypermethylation at promoter
CpG islands is one of the major events in human tumorigenesis. Promoter methylation is …

Hypermethylation of CpG islands in gene promoter regions is an important mechanism of
gene inactivation in cancer. Many cellular pathways, including DNA repair, are inactivated …

To explore the role of aberrant hypermethylation of cancer-related genes, such as P16,
MGMT, and hMLH1, in the esophageal squamous cell carcinoma (ESCC) as well as its …

Gastric cancer has striking heterogeneity in histological pattern, cellular phenotype,
genotype, biomarkers, and biological behavior. We focused on the specific morphological …

Background: Promoter genomic DNA methylation is an important inactivation mechanism of
tumor suppressor genes. This genetic-molecular pathway for cancer may separate a subset …

BACKGROUND & AIMS:: Methylation of the hMLH1 promoter region has been suggested to
cause microsatellite instability (MSI) in sporadic colorectal carcinoma (CRC). We studied the …

Global hypomethylation has been shown to increase genome instability potentially leading
to increased cancer risk. We determined whether global methylation in blood leukocyte DNA …

The development and progression of gastric cancer involves a number of genetic and
epigenetic alterations of tumor suppressor and tumor-related genes. The majority of …

Epigenetic alterations, represented by aberrant DNA methylation, are deeply involved in
human cancers. In gastric cancers, tumor-suppressor genes are inactivated more frequently …