Background Methylation of the MLH1 promoter region has been suggested to be a major
mechanism of gene inactivation in sporadic microsatellite instability-positive (MSI-H) …

Cancers arise as a consequence of multiple genetic and epigenetic alterations. Many genes
aberrantly methylated in cancers have been identified in recent years, and their use in …

OBJECTIVE: The study is designed to elucidate the relationship between epigenetic
silencing of the hMLH1 (human MutL homologue 1) gene and microsatellite instability (MSI) …

Recent studies have demonstrated that the majority of sporadic colorectal carcinomas with
replication error (RER) do not harbor mutations of the hMLH1 and hMSH2 genes that …

Hypermethylation of the hMLH1 promoter is observed in the majority of sporadic gastric
carcinomas with high frequency microsatellite instability (MSI), and it contributes to the …

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite
instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG island …

Small bowel adenocarcinoma (SB‐AC) is a very rare tumor entity. Epigenetic alterations,
including hypermethylation of DNA mismatch repair genes and tumor suppressor genes …

Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-
suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers …

CpG island hypermethylation is frequently found during gastric carcinogenesis. We
investigated methylation profiles of p16, LOX, HAND1, THBD, p41ARC, and APC along …

INTRODUCTION Hypermethylation of the promoter region of the hMLH1 gene is associated
with absent expression of MLH1 protein in sporadic colorectal cancers with microsatellite …