Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical
loading may be the most important external factor regulating the development and long‐term …

Osteoarthritis (OA) is characterized by the breakdown of articular cartilage that is mediated
in part by increased production of matrix metalloproteinases (MMPs) and aggrecanases …

There is an urgent demand for long term solutions to improve osteoarthritis treatments in the
ageing population. There are drugs that control the pain but none that stop the progression …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

The development, maintenance, and destruction of cartilage are regulated by mechanical
factors throughout life. Mechanical cues in the cartilage fetal endoskeleton influence the …

Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative
contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in …

To withstand physiological loading over a lifetime, human synovial joints are covered and
protected by articular cartilage, a layer of low-friction, load-bearing tissue. The unique …

▪ Abstract Recent studies suggest that there are multiple regulatory pathways by which
chondrocytes in articular cartilage sense and respond to mechanical stimuli, including …

Osteoarthritis is a painful and debilitating disease characterized by progressive
degenerative changes in the articular cartilage and other joint tissues. Biomechanical factors …