Activated macrophages undergo metabolic reprogramming, which drives their pro-
inflammatory phenotype, but the mechanistic basis for this remains obscure. Here, we …

Immune cell function depends on specific metabolic programs dictated by mitochondria,
including nutrient oxidation, macromolecule synthesis, and post-translational modifications …

Mitochondria are master regulators of metabolism. Mitochondria generate ATP by oxidative
phosphorylation using pyruvate (derived from glucose and glycolysis) and fatty acids (FAs) …

Profound metabolic changes are characteristic of macrophages during classical activation
and have been implicated in this phenotype. Here we demonstrate that nitric oxide (NO) …

Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various
diseases, including infection and sepsis. Although studies suggest that mitochondria may …

Macrophages are found in most tissues of the body, where they have tissue-and context-
dependent roles in maintaining homeostasis as well as coordinating adaptive responses to …

Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but
how systemic metabolism influences immune cell metabolism and function remains to be …

Macrophages generate mitochondrial reactive oxygen species and mitochondrial reactive
electrophilic species as antimicrobials during Toll-like receptor (TLR)-dependent …

Innate immune responses are intricately linked with intracellular metabolism of myeloid
cells. Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis …

Mitochondria are critical for regulation of the activation, differentiation, and survival of
macrophages and other immune cells. In response to various extracellular signals, such as …