Tocilizumab administration for the treatment of hospitalized patients with COVID‐19: a systematic review and meta‐analysis

C Kyriakopoulos, G Ntritsos, A Gogali, H Milionis… - …, 2021 - Wiley Online Library
Tocilizumab has been repurposed against the 'cytokine storm'in the setting of coronavirus
disease 2019 (COVID‐19). Our aim was to evaluate the efficacy of tocilizumab in the …

Tocilizumab in hospitalized patients with COVID-19: a meta analysis of randomized controlled trials

V Selvaraj, MS Khan, C Bavishi, K Dapaah-Afriyie… - Lung, 2021 - Springer
Background To date, only dexamethasone has been shown to reduce mortality in
coronavirus disease-19 (COVID-19) patients. Tocilizumab has been recently added to the …

Tocilizumab in COVID-19: a meta-analysis, trial sequential analysis, and meta-regression of randomized-controlled trials

TAC Snow, N Saleem, G Ambler, E Nastouli… - Intensive Care …, 2021 - Springer
Abstract Purpose Interleukin-6 (IL-6) levels discriminate between patients with mild and
severe COVID-19, making IL-6 inhibition an attractive therapeutic strategy. We conducted a …

Efficacy and safety of tocilizumab versus standard care/placebo in patients with COVID‐19; a systematic review and meta‐analysis of randomized clinical trials

D Vela, Z Vela‐Gaxha, M Rexhepi… - British Journal of …, 2022 - Wiley Online Library
Aims Tocilizumab has emerged as an important therapy in treating patients with coronavirus
disease (COVID‐19). Our purpose was to evaluate the efficacy and safety of tocilizumab …

Efficacy and safety of tocilizumab in severe and critical COVID-19: a systematic review and meta-analysis

S Rezaei, B Fatemi, Z Karimi Majd… - Expert review of …, 2021 - Taylor & Francis
Objectives Currently published papers and clinical guidelines regarding the effects of
tocilizumab in severe and critical COVID-19 are contradictory. The aim of this meta-analysis …

Tocilizumab in patients hospitalized with COVID-19 pneumonia: systematic review and meta-analysis of randomized controlled trials

S Gupta, RP Padappayil, A Bansal… - Journal of …, 2022 - journals.sagepub.com
Tocilizumab is an interleukin receptor inhibitor that has been used in patients with COVID-19
pneumonia. There are recent randomized controlled trials (RCTs) that evaluated the efficacy …

The effect of tocilizumab on mortality in hospitalized patients with COVID-19: a meta-analysis of randomized controlled trials

CS Kow, SS Hasan - European journal of clinical pharmacology, 2021 - Springer
Objective We aimed to perform a meta-analysis of randomized controlled trials (RCTs) to
summarize the overall effect of tocilizumab on the risk of mortality among patients with …

[HTML][HTML] Efficacy and safety of tocilizumab in COVID-19 patients: a living systematic review and meta-analysis, first update

IM Tleyjeh, Z Kashour, M Riaz, L Hassett… - Clinical Microbiology …, 2021 - Elsevier
Objectives Cytokine release syndrome with elevated interleukin-6 (IL-6) levels is associated
with multiorgan damage and death in severe coronavirus disease 2019 (COVID-19). Our …

[HTML][HTML] Use of tocilizumab in COVID-19: a systematic review and meta-analysis of current evidence

S Kotak, M Khatri, M Malik, M Malik, W Hassan… - Cureus, 2020 - ncbi.nlm.nih.gov
Materials and methods Online databases (PubMed and Cochrane) were searched until
June 29, 2020, for original articles investigating the immunological response in COVID-19 …

Beneficial and harmful outcomes of tocilizumab in severe COVID‐19: a systematic review and meta‐analysis

M Rubio‐Rivas, CG Forero… - … : The Journal of …, 2021 - Wiley Online Library
Introduction The results of studies of tocilizumab (TCZ) in COVID‐19 are contradictory. Our
study aims to update medical evidence from controlled observational studies and …