Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

Background The complement system is part of the innate immune system that clears
pathogens and cellular debris. In the healthy brain, complement influences …

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on
microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 …

Background Despite its identification as a key checkpoint regulator of microglial activation in
Alzheimer's disease, the overarching role of CX3CR1 signaling in modulating mechanisms …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain.
Using a knockin mouse line in which a Td-tomato reporter is incorporated into the …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …