Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Addictions are prevalent psychiatric disorders that confer remarkable personal and social
burden. Despite substantial evidence for their moderate, yet robust, heritability (approx …

Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

Genome‐wide association (GWA) can elucidate molecular genetic bases for human
individual differences in complex phenotypes that include vulnerability to addiction. Here …

Background Classical genetic studies provide strong evidence for heritable contributions to
susceptibility to developing dependence on addictive substances. Candidate gene and …

Recent large genome-wide association studies have identified multiple confident risk loci
linked to addiction-associated behavioral traits. Most genetic variants linked to addiction …

Substantial genetic contributions to addiction vulnerability are supported by data from twin
studies, linkage studies, candidate gene association studies and, more recently, Genome …

Background Vulnerabilities to dependence on addictive substances are substantially
heritable complex disorders whose underlying genetic architecture is likely to be polygenic …

• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …