Ligand-based and energy-optimized structure-based approaches were considered to obtain
excellent candidates as AChE inhibitors. The known AChE inhibitors were utilized to …

Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to
acetate and choline in a synaptic cleft. Deficits in cholinergic neurotransmitters are linked …

Alzheimer's disease (AD), a progressive neurodegenerative disorder is the most common
cause of dementia among elderly people. To date, the successful therapeutic strategy to …

Acetylcholinesterase (AChE) is one of the key targets of drugs for treating Alzheimer's
disease (AD). Tacrine is an approved drug with AChE-inhibitory activity. In this paper, 3D …

The efficacy of 40 synthesized variants of 3, 5-diaryl-1H-pyrazole and spiropyrazoline'
derivatives as acetylcholinesterase inhibitors is verified using a quantitative three …

Alzheimer's disease (AD) is a chronic neurodegenerative disease which leads to the
gradual loss of neuronal cells. Several hypotheses for AD exists (eg, cholinergic, amyloid …

Carbamates are well known for AChE as well as MAO inhibition. In this study, atom-based
3D-QSAR model generation, virtual screening, and molecular docking studies were …

Alzheimer's disease (AD) is a progressive neurological disorder responsible for the
cognitive dysfunction and cognitive impairment in the patients. Acetylcholinesterase …

Although the mechanism of Alzheimer's disease (AD) is still not fully understood, the
development of multifunctional AChE inhibitors remains a research focus for AD treatment …

The inhibition of abnormal amyloid β (Aβ) aggregation has been regarded as a good target
to control Alzheimer's disease. The present study adopted 2D-QSAR, HQSAR and 3D QSAR …