Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …

Over the last decade, our understanding of the physiological role of senescent cells has
drastically evolved, from merely indicators of cellular stress and ageing to having a central …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

Cellular senescence, a state of irreversible cell cycle arrest, is a robust mechanism used to
mediate tumor suppression and control the tissue damage response following short-term …

Aging is the largest risk factor for most chronic diseases, which account for the majority of
morbidity and health care expenditures in developed nations. New findings suggest that …

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest.
It is commonly believed to underlie organismal aging and age-associated diseases …

Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …