One of the most intriguing enzymes of sphingolipid biology is acid sphingomyelinase
(ASMase). In a phospholipase C reaction, ASMase catalyzes the cleavage of the …

Macrophages play a central role in innate immune responses, in disposal of cholesterol, and
in tissue homeostasis and remodeling. To perform these vital functions macrophages …

Although important for cellular stress signaling pathways, the molecular mechanisms of acid
sphingomyelinase (ASMase) activation remain poorly understood. Previous studies showed …

Sphingomyelinase (SMase) stimulation and subsequent ceramide generation are
suggested to be involved in signal transduction of stress‐induced apoptosis. We now show …

Ceramidases catalyze hydrolysis of ceramides to generate sphingosine (SPH), which is
phosphorylated to form sphingosine-1-phosphate (S1P). Ceramide, SPH, and S1P are …

Abstract Acid sphingomyelinase (ASMase, ASM, SMPD1) converts sphingomyelin into
ceramide, modulating membrane properties and signal transduction. Inactivating mutations …

Ceramide, a bioactive lipid, has been extensively studied and identified as an essential
bioactive molecule in mediating cellular signaling pathways. Sphingomyelinase …

Increasingly recognized as bioactive molecules, sphingolipids have been studied in a
variety of disease models. The impact of sphingolipids on cancer research facilitated the …

Sphingomyelin and its metabolic products are now known to have second messenger
functions in a variety of cellular signaling pathways. At the epicenter of the sphingomyelin …

Our understanding of the functions of ceramide signaling has advanced tremendously over
the past decade. In this review, we focus on the roles and regulation of neutral …