The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking
and is central to many cellular functions. Failure of the ER's adaptive capacity results in …

The endoplasmic reticulum (ER) is a critical organelle for normal cell function and
homeostasis. Disturbance in the protein folding process in the ER, termed ER stress, leads …

Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling
network that coordinates adaptive and apoptotic responses. There is accumulating evidence …

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis
cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response …

The endoplasmic reticulum (ER) is most notable for its central roles in calcium ion storage,
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …

The endoplasmic reticulum (ER) stress response, also commonly known as the unfolded
protein response (UPR), is an adaptive response used to align ER functional capacity with …

The endoplasmic reticulum (ER) plays a crucial role in protein folding, assembly, and
secretion. Disruption of ER homeostasis may lead to accumulation of misfolded or unfolded …

Background The global rise of metabolic disorders, such as obesity, type 2 diabetes, and
cardiovascular disease, demands a thorough molecular understanding of the cellular …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …

The endoplasmic reticulum (ER) is an organelle in which newly synthesized secretory and
transmembrane proteins are assembled and folded into their correct tertiary structures …