There are a number of examples of sex differences in drug pharmacokinetics and
pharmacodynamics. Recent advances in the characterisation of specific isozymes involved …

Several years ago regulatory authorities requested to include women in all phases of clinical
drug development in order to thoroughly investigate potential gender differences in the …

Gender-related differences in pharmacokinetics have frequently been considered as
potentially important determinants for the clinical effectiveness of drug therapy. The …

Pharmacological response depends on multiple factors and one of them is sex–gender.
Data on the specific effects of sex–gender on pharmacokinetics, as well as the safety and …

In this review I have attempted to summarize gender differences in pharmacokinetics
involving the cytochrome P450 (CYP) isozymes of young and mature adults, excluding the …

Biologic differences exist between men and women that can result in differences in
responses to drugs. Both pharmacokinetic and pharmacodynamic differences between the …

Significant differences that exist between the sexes affect the prevalence, incidence and
severity of a broad range of diseases and conditions. Men and women also differ in their …

Historically, women, the elderly, and minorities were underrepresented in clinical drug trials.
Information on possible gender-related differences in the pharmacokinetics of drugs is often …

The is growing awareness that the underrepresentation of women in clinical trials and in
particular in phase I studies may lead to incorrect handling of drugs. Despite the fact that …

There is an increasing awareness that the exclusion of women from clinical trials may lead
to inaccurate application of drug therapy in women. Gender and estrus cycle differences in …